The Senegal international forward had impressed new Liverpool manager Jurgen Klopp with 25 goals in 75 games for Saints and quickly became a key player at Anfield, helping the club to win the Champions League (2019), Club World Cup (2019), FA Cup (2022) and Carabao Cup (2022), while also ensuring an end to their 30-year wait for a Premier League title in 2020.
Mane has now opted to move on for a new challenge with Bayern Munich, with the 30-year-old undergoing a medical in Germany on Tuesday ahead of his €41m transfer that will end his six-year spell at Anfield. After he began to play more as a central striker for Liverpool last season following the signing of Luis Diaz, may replace the legendary Robert Lewandowski in that role at the Allianz Arena.
Here's a breakdown of the prolific output that turned Mane into a world-class player during his time at the club.
Covering ground, connecting the team
Mane pace and mobility means he can pop up all over the pitch but mainly he has operated on the left side, where he was able to forge a wonderful partnership with left-back Andy Robertson.
Connection via completed passes
Connection via chances created
Mane with Salah/Firmino
Mane goal/Salah assist: 17 (4 last season)
Salah goal/Mane assist: 12 (2 last season)
Mane goal/Firmino assist: 17 (0 last season)
Firmino goal/Mane assist: 6 (0 last season)
Salah goal/Firmino assist: 20 (1 last season)
Firmino goal/Salah assist: 10 (1 last season)
Breakdown of goals: first-time finisher
Mane scored 120 goals during his time at Anfield, with 48 assists from his 259 games.
In the Premier League, he managed 90 goals and 36 assists from 196 games.
In the Champions League, that total was 24 goals and 8 assists from 55 games.
Incredibly, 68 of Mane's 120 Liverpool goals were with his first touch (57%), showing how potent he was in finishing off so many of Liverpool's incisive attacks. But here's a breakdown of how he usually scored.
Goals by body part at Liverpool (120)
Right foot: 70
Left foot: 31
Goals by area at Liverpool (120)
Inside six-yard box: 26
Inside penalty box: 117 (inc. inside six-yard box)
Outside penalty box: 3
ESPN's Stats & Information Group contributed to this report