Fourth seed Stefanos Tsitsipas became the highest-profile casualty of the French Open men's draw as he lost in four sets to teenage Dane Holger Rune.
The 19-year-old punished a lacklustre display from the 2021 Roland Garros runner-up to triumph 7-5 3-6 6-3 6-4.
Rune had never won a Grand Slam match before this event but has dropped just one set in reaching the quarter-finals.
He meets Casper Ruud in the last eight after the Norwegian also won in four sets, beating Hubert Hurkacz.
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