Laura Keates has been withdrawn from England's squad at the 2021 Rugby World Cup in New Zealand.
The Worcester prop, 34, suffered an anterior cruciate ligament (ACL) injury in training.
Keates will remain with family in New Zealand for the remainder of the tournament, with the pool stage concluding this weekend.
Loughborough Lightning's Detysha Harper has been called up as a replacement and will link up with the squad on Monday.
Flanker Marlie Packer will captain England for the first time in their final pool game against South Africa on Sunday.
The Red Roses will field an almost entirely changed starting XV having qualified for the quarter-finals with a statement win against France last weekend.
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