Italy full-back Ange Capuozzo will miss the rest of the Six Nations because of a shoulder injury.
Capuozzo suffered an injury to his left shoulder during the Azzurri's defeat by Ireland but remained on the field.
The 23-year-old had been named in Italy's 33-player squad for the remaining two matches against Wales and Scotland.
Italy face Wales in what is likely to be a Wooden Spoon decider in their next match on Saturday (14:15 GMT).
Capuozzo will return to his club Toulouse to continue his rehabilitation.
French-born Capuozzo scored two tries on debut against Scotland in March 2022 and created the winning score for Italy's first victory in Wales the following week.
He was named men's Breakthrough Player of the Year by World Rugby and has started the first three Six Nations games of the current campaign.
Italy have also called up uncapped Toulouse scrum-half Martin Page-Relo.
Wales coach Warren Gatland is hoping his side can beat Italy to ensure they avoid the Wooden Spoon.
With a game against France in Paris to end the campaign on Saturday, 18 March, winning in Rome is Wales' best chance of avoiding finishing at the foot of the table.
Capuozzo played a crucial role as Italy made history by beating Wales in Cardiff on the final day of the 2022 tournament.
He made the memorable break that led to Edoardo Padovani's last-gasp try, converted by Paolo Garbisi to seal a 22-21 win to end Italy's seven-year Six Nations losing streak.
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