Wales are aiming to beat England for only a third time in Women's Six Nations history when they take on the Red Roses on Saturday.
It is a top-of-the-table match between teams who have won their opening two games with bonus points.
For Wales, having beaten Ireland and Scotland, the Triple Crown is within their grasp in front of a sell-out Cardiff Arms Park crowd.
More than 8,000 tickets have been sold for the encounter in the Welsh capital.
Wales have made two changes as they look to keep momentum, Hannah Bluck replaces injured centre Kerin Lake while Lowri Norkett makes her first Six Nations start on the wing. She comes in for Carys Williams-Morris, who is away playing for the RAF.
England had 19 players unavailable before their convincing second-round win over Italy, but welcome back four players from injury, including Alex Matthews at number eight.
Full-back Emma Sing makes her first Red Roses start.
Two players are set to win first caps from the bench, Bryonie King for Wales and May Campbell for England.
England are top of World Rugby's rankings and are on a 21-match winning streak in the Six Nations.
Wales have risen to eighth in the world and will be looking to repeat the heroics of the class of 2015 when they ran out 13-0 winners at St Helen's, Swansea.
A few faces still remain in the squad from that day, including Elinor Snowsill, Sioned Harries, Carys Phillips, Caryl Thomas, Keira Bevan and Robyn Wilkins.
The two sides met in September in a World Cup warm-up game at Ashton Gate, Bristol, where England ran in 11 tries in a 73-7 demolition of Wales.
That victory also saw them become the first team in history to win 25 Tests in a row, a winning streak that continued all the way to the final of the World Cup, where they lost to hosts New Zealand.
View from the camps
Wales head coach Ioan Cunningham said: "We understand where we are on our journey and we realise where England are.
"We have come a long way, but we have got such a long way to go as well.
"You look at England - they are number one in the world, 32 games on the bounce before the final. They average 65 points a game and only concede five.
"Their domestic league is probably the best in the world so we put that into perspective, but we are also making big strides ourselves and we are excited by the challenge.
"It's a Triple Crown game at home in Cardiff with a sell-out crowd, so we can't wait."
England head coach Simon Middleton said: "Their intention will be to win. You always believe that. I think their ambitions will be sky-high and rightly so.
"It's a great test for us as well. We're developing our squad. They've said it will be a mark of where they are at and we are on the same lines.
"As a team they feel very together, very connected and very strong.
"Whereas before we have been able to overpower them, like we have with a lot of teams because of the physical thing that comes with full-time contracts, that won't be there to the extent that it has been previously.
"It will be an ongoing arm-wrestle, which is great because then it comes down to tactics."
Line-ups
Wales: Keight; Neumann, H Jones (capt), Bluck, Norkett; Snowsill, Bevan; Pyrs, K Jones, Tuipulotu, Fleming, G Evans, B Lewis, Callender, Harries.
Replacements: C Phillips, Hope, Hale, John, K Williams, King, F Lewis, Wilkins.
England: Sing; Breach, Tuima, Heard, Dow; Aitchison, L Packer; Carson, Davies, Bern, Aldcroft, O'Donnell, Kabeya, M Packer (capt), Matthews.
Replacements: Campbell, Botterman, Muir, Burns, Beckett, Wyrwas, McKenna, Kildunne.
Match facts
Head to head
Wales
England
Match officials
Referee: Joy Neville (IRFU)
Assistants: Beatrice Benvenuti (FIR), Maria Pacifico (FIR)
TMO: Olly Hodges (IRFU)