Manchester City kick off their defence of the Premier League title at newly promoted Burnley, while Mauricio Pochettino will begin his reign at Chelsea against Liverpool.
Burnley, managed by City legend Vincent Kompany, is the opening game of the season on Friday, Aug. 11.
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Luton Town, who are back in the English top flight for the first time since 1992, begin away at Brighton. Fellow Premier League newcomers Sheffield United play Crystal Palace at Bramall Lane.
Kenilworth Road will become the smallest ground to host a Premier League fixture when Luton play Burnley on Aug. 19.
New Tottenham manager Ange Postecoglou starts his reign away at Brentford; Harry Kane's future at the club is still uncertain.
Spurs face a difficult end to their season with consecutive games against Newcastle, Man City, Arsenal and Liverpool in April and May.
Newcastle United face a tricky start to their season, playing five of last season's top eight in their first five fixtures. They open at home to Aston Villa before facing Man City (away), Liverpool (home), Brighton (away) and Brentford (home).
The first Manchester derby of the season will be played on Oct. 28 at Old Trafford. The reverse fixture at the Etihad is March 2, with Guardiola's side travelling to Anfield the following weekend on March 9.
After an unexpected title challenge last campaign, Arsenal face Nottingham Forest at the Emirates on the opening weekend before playing Palace (away), Fulham (home) and Manchester United (home).
Last season's top two first meet on Oct. 7 in north London with Mikel Arteta's side facing Man City in the reverse fixture on March 30.
Pochettino's Chelsea rebuild will face a challenge in November with a return to former club Tottenham on Nov. 4, followed by fixtures against Man City (home) and Newcastle (away).