No. 10 Oregon football handled No. 19 Colorado in their Pac-12 opener with a 42-6 win in Eugene on September 23, 2023. Bo Nix had four total touchdowns and had 276 passing yards. Troy Franklin caught eight passes for two scores and 126 yards. The Oregon defense sacked Shedeur Sanders seven times. Michael Harrison caught the lone touchdown for the Buffaloes.

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