A bonus-point win over England would see Ireland retain their title and set up the chance to seal successive Six Nations Grand Slams for the first time.

They are understandably big favourites to beat an England side still smarting after their heavy defeat by Scotland.

After they began with two victories, the Red Rose will be desperate to stop another campaign grinding to a halt.

Should they lose against Ireland and away to France they would finish on two wins for a fourth successive Six Nations, a damaging backwards step after coming third at the World Cup.

In the aftermath of the Scotland loss, coach Steve Borthwick has been criticised by pundits for being too reliant on data after their attack again failed to fire.

No such problems for Andy Farrell's free-scoring Ireland, who are just two wins away from becoming the only side to record back-to-back Grand Slams in the Six Nations era.

Team news

England: Head coach Steve Borthwick has made three changes to his starting XV, headlined by Immanuel Feyi-Waboso being given his first Test start in place of Elliot Daly. Scrum-half Danny Care is set to win his 100th cap as a replacement with the fit-again Alex Mitchell given his starting berth.

Lock George Martin comes in for Ethan Roots, with Ollie Chessum switching to blind-side flanker and Alex Dombrandt replacing Martin on the bench. George Ford keeps his place at fly-half ahead of the returning Marcus Smith, who is named among the replacements.

Ireland: Hugo Keenan returns at full-back after a knee injury in the only change from the starting XV against Wales.

As a result, Ciaran Frawley moves to the bench with Stuart McCloskey dropping out of the squad.

Second row Iain Henderson has recovered from a toe problem to take James Ryan's place among the replacements after he was ruled out of their last two matches with a bicep injury.

Prop Oli Jager is not fit enough to make the squad so Finlay Bealham comes in. Centre Garry Ringrose is not included in the matchday 23 despite returning to fitness.

Commentator's notes

Andrew Cotter: Despite recent form there is a feeling that England might be able to cause Ireland some problems, but to do so they at least have to match the power of the visitors - hence the selection of Martin at lock with Chessum moving to blindside.

A direct, simple game plan orchestrated by Ford may well be the best chance for a home win.

Ireland, though, have such clarity in their style of play and their execution. They also have continuity of selection.

Twickenham will hope that England at least rattle the visitors, but odds are heavily on another Irish victory on their way to the championship.

View from both camps

England head coach Steve Borthwick on Danny Care potentially winning 100 caps: "Danny has been a tremendous servant to English rugby and reaching this milestone is an incredible achievement. He's a wonderful player and someone who always puts the team first.

"I'm sure Saturday will be an emotional and memorable day for Danny and his family, and the team couldn't be prouder of his accomplishment."

Ireland head coach Andy Farrell on England: "I look at the individuals, the way they are playing, the coaching staff they have, the plan they have, and it's a fantastic side that is going to be preparing to give it everything they've got.

"That makes them unbelievably dangerous. We just prepare for them to be at their best and if that's the case it's going to be one hell of a battle.

"If they're at their best, you expect them to be as hard as anyone in world rugby to beat."

Line-ups

England: 15-Furbank, 14-Feyi-Waboso, 13-Slade, 12-Lawrence, 11-Freeman; 10-Ford, 9-Care; 1-Genge, 2- George (capt), 3-Cole, 4-Itoje, 5-Martin, 6-Chessum, 7-Underhill, 8-Earl.

Replacements: 16-Dan, 17-Marler, 18-Stuart, 19-Dombrandt, 20-Cunningham-South, 21-Care, 22-Smith, 23-Daly.

Ireland: 15-Keenan, 14-Nash, 13-Henshaw, 12-Aki, 11-Lowe, 10- Crowley, 9-Gibson-Park; 1-Porter, 2-Sheehan, 3-Furlong, 4-McCarthy, 5-Beirne, 6-O'Mahony (capt), 7-Van der Flier, 8-Doris.

Replacements: 16-Kelleher, 17-Healy, 18-Bealham, 19-Henderson, 20-Baird, 21-Conan, 22-Murray, 23-McCloskey.

Match facts

Head-to-head

England

Ireland

Match officials

Referee: Nika Amashukeli (Georgia)

Touch judges: Andrea Piardi (Italy) & Craig Evans (Wales)

TMO: Ben Whitehouse (Wales)