ATLANTA -- The Dallas Cowboys lost quarterback Dak Prescott to a hamstring injury late in the third quarter of Sunday's 27-21 loss to the Atlanta Falcons.

The Cowboys were trailing 27-13 when Prescott was ruled out with 11:08 to play in the fourth. Television replays showed Prescott grimace after a 10-yard completion to Jalen Brooks on the Cowboys' final drive of the third quarter.

Prescott had a season-high 30 yards rushing, including a 22-yard gain on a second-quarter scoring drive. It was the Cowboys' longest run of the season and Prescott entered the game with 24 yards rushing on the season.

Prescott completed 18 of 24 passes for 133 yards and a touchdown before he left. Replays also showed Prescott with a swollen hand, but the Cowboys have not made an announcement about a possible injury to his hand.

Cooper Rush replaced Prescott and had 115 yards to go along with a touchdown. He played in two games this season in mop-up duty, completing 9 of 14 passes for 52 yards and an interception. In 2022, he went 4-1 as the Cowboys starter after Prescott suffered a broken right thumb in the season opener.

In 2020, Prescott missed 11 games with a dislocation and fracture of his right ankle. He missed one game in 2021 because of a right calf strain. Since breaking his thumb, he had made 36 straight starts, including Sunday.

With Prescott out, Trey Lance, who has served as the No. 3 quarterback since the Cowboys acquired him from the San Francisco 49ers last year, is the backup quarterback.