TAMPA, Fla. -- The Buccaneers believe that All-Pro left tackle Tristan Wirfs suffered a sprained MCL in the first half Sunday against the 49ers, a source told ESPN's Jeremy Fowler.

The three-time Pro Bowl selection and team captain will require additional testing, including an MRI, to determine the severity, the source told Fowler.

Wirfs suffered the injury on a third-and-7 play with 5:06 to go in the second quarter. He was lining up against Nick Bosa while pass blocking when the injury occurred.

He was replaced by former 49ers offensive tackle Justin Skule, who played for San Francisco from 2019 to 2021. Skule started four games this season at right tackle when Luke Goedeke was sidelined with a concussion.

The Buccaneers are already without Pro Bowl wide receiver Chris Godwin, who suffered a dislocated left ankle and is out for the season. Wide receiver Mike Evans has been out for three games with a hamstring strain, but the hope is he can return after the Buccaneers' Week 11 bye.