'An example for us all' - Del Potro's emotional goodbye to tennis
Written by I Dig SportsRoger Federer, Rafael Nadal, Carlos Alcaraz and Gael Monfils featured in a video tribute to the Argentine.
Del Potro beat five-time defending champion Federer to win the US Open in 2009.
He reached the final in New York again in 2018 but lost to Djokovic.
A popular player with a huge forehand, Del Potro won two Olympic medals - bronze in 2012 and silver four years later.
He claimed 22 ATP singles titles in his career and was as high as number three in the world rankings.
However, a wrist injury derailed his career after his US Open victory before he seriously injured his knee at Queen's in 2019.
Del Potro released a video on Instagram last week, external discussing the long-term impact injuries have had on his body.
"My daily life isn't what I would like it to be. It's very tough. There are moments where I have no more strength," he said.
"I'm not indestructible. I have good things, bad things but most of the time I have to fake it and put on a good face, but many times I feel terrible.
"Since that moment [after surgery in 2019], I was never able to climb stairs without pain.
"I hurts when I drive, it hurts many times when I go to sleep. It's been a never-ending nightmare."