England have won 20 of their previous 22 Six Nations matches against Wales, and given the strong team named by Mitchell, matching their average winning margin (over the last eight championship wins) of 46 points looks likely.

World player of the year Ellie Kildunne, who scored two tries against Wales in last year's 46-10 victory, returns to the starting XV to win her 50th cap.

The 25-year-old full-back is joined by wings Abby Dow and Jess Breach, with the trio ready to chase down their 18 combined tries in last year's championship.

Zoe Harrison gets an opportunity to press forward her case to be the starting fly-half in a star-studded backline also containing regular centres Meg Jones and Tatyana Heard.

Quality returns to the pack in the form of prop Sarah Bern, who was at her barnstorming best off the bench in York, while 22-year-old Morwenna Talling and Abbie Ward form a balanced second-row partnership that brings work-rate and line-out nous.

"You could field two completely England different 23s and both could win the Six Nations, that is the calibre we are talking about," former Wales player Philippa Tuttiett told BBC's Rugby Union Weekly.

"There are some superstars throughout that team, it is an incredible team."

To cap off the exciting team selection, Olympian Abi Burton, who nearly lost her life in 2022, is set to make her England debut from the bench.

The 25-year-old back row spent 25 days in an induced coma after being diagnosed with autoimmune encephalitis, which occurs when the body's immune system mistakenly attacks the brain.

When Burton came out of her coma she was unable to walk and talk, and had lost more than three stone, but she miraculously returned to rugby sevens in time for her second Olympics in Paris.

England centre Jones said when Burton came out of her coma she "manifested" playing for the Red Roses and the back rower has impressed following her switch back to XVs with Trailfinders.

"Since I've been ill and come back into playing rugby at the Paris Olympics and coming back into XVs, I feel like I am thriving as a person on and off the pitch," Burton told BBC Sport.

"My family are now finally seeing me fully play rugby like I will never play again, every single game, and they love seeing that enjoyment on face.

"It will be a really special moment for them just seeing me happy and enjoying myself."