Only two of Saracens' England players will feature for the European champions when they begin the defence of their Heineken Champions Cup at Racing 92.
Scrum-half Ben Spencer, a late call-up as cover for the World Cup final, and reserve hooker Jack Singleton will start the repeat of the 2016 final.
Scotland talisman Finn Russell will start at fly-half on Sunday for the hosts, who are 10th in the Top 14.
Former Ireland winger Simon Zebo is named on the bench.
Sarries' academy graduate Jackson Wray will make his 50th Champions Cup appearance from number eight, while Wales prop Rhys Carre will make his club debut.
"I'm very proud to reach 50 games in Europe," said Wray. "It's a great number to hit in the best competition in the world."
World Cup-winning South Africa prop Vincent Koch is named among the replacements, alongside Springbok versatility back Damian Willemse.
Racing 92: Dulin; Thomas, Vakatawa, Chavancy, Imhoff; Russell, Machenaud; Ben Arous, Chat, Gomes Sa, Ryan, Palu, Lauret, Chouzenoux, Claassen
Replacements: Baubigny, Kolingar, Oz, Bird, Mangene, Iribaren, Volavola, Zebo
Saracens: Gallagher; Maitland, Lozowski, Tompkins, Segun; Vunipola, Spencer; Carre, Singleton, Lamositele, Skelton, Hunter-Hill, Isiekwe, Earl, Wray
Replacements: Gray, Crean, Koch, Kpoku, Reffell, Whiteley, Willemse, Taylor