Reigning European champions Saracens will be without much of their current England contingent for Saturday's trip to Thomond Park.
Owen Farrell, Mako and Billy Vunipola and Elliot Daly are among nine players to drop out of the side for the meeting with Munster.
Meanwhile the Irish province make 14 changes from the side that was defeated by Edinburgh last weekend.
Prop Stephen Archer is the only player to retain his place.
Last weekend Sarries trio Farrell, Billy Vunipola and Maro Itoje made their first appearances since returning from the World Cup in Japan for their side's 25-12 win over Bath.
However Itoje is the only member of England's starting World Cup final side to be named in Sarries' side for their trip to Limerick, with the forward moving to lock having operated at flanker last weekend.
Manu Vunipola and Ben Spencer form the half-back partnership with Brad Barritt captaining the side on his 250th appearance.
Last season's European champions currently sit bottom of the English Premiership on -18 points following their 35 point deduction.
A heavy defeat by Clermont in their Champions Cup opener means that another loss would likely signal an end to their hopes of reaching the knockout stage of this season's competition.
Munster fell to their first home defeat in nearly two years last weekend when head coach Johann van Graan fielded a largely inexperienced outfit against Edinburgh.
Unsurprisingly van Graan reverts back to his strongest available side, with Archer keeping his spot at tight-head prop as John Ryan is named among the replacements.
Tadhg Beirne is named at flanker as opposed to the second row, where he has operated for the majority of his time at the province.
Munster: Haley; Conway, Farrell, R Scannell, Earls; Hanrahan, Murray; Cronin, N Scannell, S Archer; Kleyn, Holland; Beirne, O'Mahony, Stander.
Replacements: O'Byrne, O'Connor, Ryan, Wycherley, O'Donoghue, McCarthy, Arnold, Botha.
Saracens: Gallagher; Segun, Lozowski, Barritt, Lewington; Manu Vunipola, Spencer; Barrington, Singleton, Lamositele, Skelton, Itoje; Isiekwe, Earl, Wray.
Replacements: Pifeleti, Carre, Ibuanokpe, Kpoku, Reffell, Whiteley, Malins, Tompkins.