England winger Jonny May scored two of Leicester's nine tries as they beat Italian club Calvisano to take control of European Challenge Cup Pool 5.
May's tries came inside the opening 11 minutes after Manu Tuilagi had opened the scoring before Sam Lewis sealed a bonus point before half-time.
Tommy Reffell, Adam Thompstone, Jake Kerr, Noel Reid and Telusia Veainu completed Tigers' third pool win.
Tigers could now seal a quarter-final with victory in Calvisano next week.
Tigers head coach Geordan Murphy picked a strong side, including England World Cup quintet Tuilagi, May, George Ford, Ben Youngs and Dan Cole.
The gulf in class between the sides was quickly apparent against opposition who have now conceded 99 points in two defeats so far in the competition.
Murphy also included a rising star in Wales Under-20 flanker Reffell, who began the scoring in the second half as Tigers became the first English side to win their opening three Challenge Cup games since Wasps in 2002.
The European Challenge Cup has provided succour in a poor season so far for Tigers, who have only won one of five Premiership matches, with only Saracens' 35-point deduction keeping them off the bottom of the table.
Leicester: Steward; Thompstone, Tuilagi, Reid, May; Ford, B Youngs; Gigena, T Youngs (capt), Cole, Lewis, Green, Coghlan, Reffell, Kalamafoni
Replacements: Kerr, Leatigaga, Heyes, Boladau, Thompson, Harrison, Hardwick, Veainu
Calvisano: Trulla; Panceyra-Garrido (capt), De Santis, Mazza, Susio; Pescetto, Casilio; Brugnara, Luccardi, Cittadini, Zambonin, Zanetti, Izekor, Martani, Vunisa
Replacements: Morelli, Barducci, Leso, Venditti, Koffi, Consoli, Chiesa, Mori
Referee: Craig Evans (Wales)
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