Reading and U.S. international defender Matt Miazga is looking at a significant spell on the sidelines after suffering a torn ankle ligament, according to Reading manager Mark Bowen.

Miazga was stretchered off in the 66th minute of Saturday's 2-2 FA Cup draw with Cardiff City. Bowen disclosed the extent of Miazga's injury following Tuesday's 1-0 league defeat to Bristol City.

"Miazga has a grade two tear -- he'll be out for a significant amount of time," Bowen said.

The injury puts Miazga's participation for the U.S. during the March international window in jeopardy. The U.S. is scheduled to play the Netherlands on March 26 (live on ESPN2 at 3:45 p.m. ET), followed by a match with Wales four days later.

Miazga, 24, is in his second season with the Royals while on loan from Premier League side Chelsea. He's made 19 league and cup appearances during the current campaign, scoring one goal.