Ireland will hope their impressive home form will help them end Wales' unbeaten run in the Six Nations when they come face to face in Dublin on Saturday.
Ireland, who beat Scotland 19-12 last weekend, have won 16 of their last 17 Tests at the Aviva Stadium.
Wales are seeking a ninth Six Nations victory in a row to equal their longest winning run in the Championship.
They ran in five tries in their triumph over Italy last week but clearly face a far sterner examination this time out.
Ireland's Garry Ringrose and Caelan Doris are injured, so centre Robbie Henshaw and flanker Peter O'Mahony are promoted to the starting line-up.
O'Mahony will begin as blind-side flanker, with CJ Stander switching to number eight.
Uncapped back row Max Deegan and fit-again utility back Keith Earls are amongst the replacements.
Centre Nick Tompkins starts his first Wales game in the only change to the side that began against Italy.
George North started against the Azzurri at outside centre but reverts to a more familiar position on the wing, meaning Johnny McNicholl drops to the bench.
Scrum-half Gareth Davies, prop Rhys Carre and lock Adam Beard are named as replacements, coming in for Rhys Webb, Rob Evans and Cory Hill, who misses out through a leg injury.
Wales had named Owen Williams as fly-half replacement, but he was a late withdrawal because of a hamstring strain and Jarrod Evans regained his place as back-up.
View from both camps
Ireland head coach Andy Farrell on whether his team's confidence could suffer following a narrow win against Scotland: "I don't think their egos are bruised. They can't wait to get back on the field.
"We're in a good place, we're brimming, ready for what we know is going to be a really, really tough game.
"We know that Wales are Grand Slam champions and semi-finalists at the World Cup and rightly so.
"They're being talked up as a great team. We know what's coming this week, we get excited by that as well."
Wales head coach Wayne Pivac: "Momentum is important in the Championship. It was nice to get a good winning start under our belts, and hopefully we can build on that through the tournament.
"Ireland are a very physical team and if they get on the front foot they can be dangerous.
"We have to match that. It's not an easy place to go. It will be a big challenge. We have to front up physically."
Line-ups
Ireland: 15-Jordan Larmour, 14-Andrew Conway, 13-Robbie Henshaw, 12-Bundee Aki, 11-Jacob Stockdale, 10-Johnny Sexton (captain), 9-Conor Murray; 1-Cian Healy, 2-Rob Herring, 3-Tadhg Furlong, 4-Iain Henderson, 5-James Ryan, 6-Peter O'Mahony, 7-Josh van der Flier, 8-CJ Stander.
Replacements: 16-Ronan Kelleher, 17-Dave Kilcoyne, 18-Andrew Porter, 19-Devin Toner, 20-Max Deegan, 21-John Cooney, 22-Ross Byrne, 23-Keith Earls.
Wales: 15-Leigh Halfpenny; 14-George North, 13-Nick Tompkins, 12-Hadleigh Parkes, 11-Josh Adams; 10-Dan Biggar, 9-Tomos Williams; 1-Wyn Jones, 2-Ken Owens, 3-Dillon Lewis, 4-Jake Ball, 5-Alun Wyn Jones (captain), 6-Aaron Wainwright, 7-Justin Tipuric, 8-Taulupe Faletau.
Replacements: 16-Ryan Elias, 17-Rhys Carre, 18-Leon Brown, 19-Adam Beard, 20-Ross Moriarty, 21-Gareth Davies, 22-Jarrod Evans, 23-Johnny McNicholl.
Match facts
Head-to-head
Ireland
Wales
Match officials
Referee: Romain Poite (France)
Touch judges: Luke Pearce (England) & Mike Fraser (New Zealand)
TMO: Glenn Newman (New Zealand)