Matt Garvey will make his first start for Gloucester in Friday's West Country Derby at Kingsholm.
He is one of two changes to the Cherry and Whites line-up, with Louis Rees-Zammit playing at full-back.
Kyle Sinckler will make his first start for Bristol Bears, having come off the bench to make his debut against Saracens last weekend.
Max Malins and Ben Earl, both on loan from Sarries, also come into the starting line-up for the first time.
Gloucester: Rees-Zammit; Thorley, Harris, Twelvetrees, May; Cipriani, Simpson; Rapava-Ruskin, Singleton, Balmain, Slater, Garvey, Ackermann, Ludlow, Polledri.
Replacements: Marais, Mulipola, Stanley, Drake, Clement, Varney, Seabrook, Sharples.
Bristol Bears: Malins; Leiua, Radradra, Piutau, Purdy; Sheedy, Uren; Woolmore, Thacker, Sinckler, Joyce, Vui, Luatua (capt), Earl, Hughes.
Replacements: Capon, Thomas, Lahiff, Holmes, Thomas, Randall, Eden, Morahan.
Phone: (800) 737. 6040
Fax: (800) 825 5558
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