Manu Tuilagi will start for Sale Sharks when they face Leicester Tigers, the first time the England centre has played against his former side since leaving Welford Road in July.
Leicester make 13 changes for the visit of their second-placed opponents in round 18 of the Premiership season.
Tomas Lavanini and Charlie Clare are the only players to remain in their XV from Sunday's loss to Gloucester.
Sale, who thrashed Bristol last time around, exchange Ben Curry for his brother Tom in their line-up as Jono Ross returns to captain the side.
The fixture will be the first time a Tuilagi brother has started a fixture for the visiting team at Leicester since 2010.
Leicester: Steward; Williams, Taute, Scott; Nadolo, Ford (capt); Youngs, Genge, Clare, Cole, Lavanini, Green, Wells, Wallace, Liebenberg.
Replacements: Kerr, Gigena, Leatigaga, Henderson, Taufafa, White, Henry, Porter.
Sale: L James; Solomona, Tuilagi, van Rensburg; Yarde, MacGinty; de Klerk, Oosthuizen, van der Merwe, Cooper-Woolley, JL du Preez, de Jager, Ross (capt), Curry, D du Preez.
Replacements: Ashman, Morozov, John, Neild, Postlethwaite, Quirke, S James, Reed.