Bristol Bears make nine changes after Friday's bonus-point win at Worcester, with captain Siale Piutau missing out after being banned.
Pat Lam's men begin round 19 of the campaign third in the table, two points behind second-placed Sale.
Northampton name a youthful side with 15 changes from their defeat by leaders Exeter Chiefs last time out.
Scrum-half Tom James makes his first start for the Saints, who are looking to avoid a fourth straight defeat.
The visitors are 10 points off the play-off places with only four matches of the regular season remaining.
Piutau will miss three games after accepting a charge of striking an opponent during the match against the Warriors.
Fly-half Callum Sheedy skippers the Bears in place of the Tonga centre.
Bristol Bears: C Piutau; Morahan, Radradra, O'Conor, Leiua; Sheedy (capt), Uren; Woolmore, Thacker, Sinckler, Attwood, Joyce, Vui, Earl, Hughes.
Replacements: Capon, Y Thomas, McCabe, Luatua, D Thomas, Cook, Malins, Lloyd.
Northampton Saints: Freeman; Olowofela, Dingwall, Francis, Naiyaravoro; Grayson, James; Hobbs-Awoyemi, Haywood, Painter, Moon, Isiekwe, Gibson, Ludlam (capt), Adendorff.
Replacements: Marshall, Auterac, Garside, Bean, Uru, Taylor, Bird-Tulloch, Gillespie.
Referee: Tom Foley.
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