Hooker Sam Matavesi comes in as one of three Northampton changes for the visit of Premiership play-off hopefuls Sale.
Scrum-half Alex Mitchell and number eight Shaun Adendorff are also brought into the starting XV following their recent Champions Cup quarter-final defeat by Exeter.
England duo Manu Tuilagi and Tom Curry, and World Cup-winning South Africa scrum-half Faf de Klerk start for Sale.
The trio were replacements in their Premiership Cup win last week.
Northampton Saints: Furbank; Proctor, Dingwall, Hutchinson, Tuala; Biggar, Mitchell; Iyogun, Matavesi, Franks; Ribbans, Ratuniyarawa, Lawes, Ludlam (capt), Adendorff.
Replacements: Fish, Seville, Painter, Isiekwe, Harrison, Gibson, Taylor, Naiyaravoro.
Sale Sharks: James; Van Rensburg, S James, Tuilagi, Hammersley; R Du Preez, De Klerk; Harrison, Langdon, Oosthuizen; Wiese, JL Du Preez, Ross (capt), T Curry, D Du Preez.
Replacements: Van Der Merwe, Morozov, Cooper-Woolley, Phillips, Neild, Cliff, MacGinty, Yarde.
Referee: Wayne Barnes
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