Who should you start? Who should you sit? To help you set your fantasy football lineups and to avoid starting a player who won't be in the lineup, we'll post fantasy-relevant updates and analysis here as NFL teams release their inactives, typically about 90 minutes before kickoff. Any rankings cited in this column come from our ESPN Fantasy staff ranks.
Refresh often for the latest information.
1 p.m. ET games
Offense
Mark Ingram II, RB, BAL: Ankle -- Doubtful
Impact: Toss-up between Gus Edwards and J.K. Dobbins as to who gets the carries.
Joe Mixon, RB, CIN: Foot -- OUT
Impact: Giovani Bernard will handle the majority of RB action, but behind a depleted line.
John Ross III, WR, CIN: Illness -- Doubtful
Impact: Barring a trade, this disgruntled player may not have fantasy value again this season.
Austin Hooper, TE, CLE: Appendix -- OUT
Impact: Harrison Bryant/David Njoku get another week to shine.
Aaron Jones, RB, GB: Calf -- OUT
Impact: It's Jamaal Williams time once again in Green Bay.
Mason Crosby, K, GB: Calf -- Questionable
Impact: No alternative was signed, but Crosby remains risky.
Mo Alie-Cox, TE, IND: Knee -- Questionable
Impact: You weren't starting him anyway. Reminder: WR Michael Pittman Jr. returns from IR.
Sammy Watkins, WR, KC: Hamstring -- OUT
Impact: Mecole Hardman versus the Jets? That's a possible flex gamble.
Tyler Higbee, TE, LAR: Hand -- Questionable
Impact: Leaning toward being active, but Gerald Everett looms regardless.
Bryan Edwards, WR, LV: Ankle -- Questionable
Impact: Nelson Agholor has already surpassed him on the team's WR depth chart.
Dalvin Cook, RB, MIN: Groin -- Questionable
Impact: Fully expected to play without restrictions.
Damien Harris, RB, NE: Ankle -- Questionable
Impact: Looks like he'll play, but this offense is in shambles.
Julian Edelman, WR, NE: Knee -- OUT/IR
Impact: Damiere Byrd, Gunner Olszewski, and Jakobi Meyers all enter the WR mix ...
N'Keal Harry, WR, NE: Concussion -- OUT
Impact: ... as does super-long-shot Isaiah Zuber.
Frank Gore, RB, NYJ: Hand -- Questionable
Impact: It could be time to pass the baton to La'Mical Perine.
Jamison Crowder, WR, NYJ: Groin -- Doubtful
Impact: A strong debut last week from Denzel Mims may repeat.
Breshad Perriman, WR, NYJ: Concussion -- OUT
Impact: Braxton Berrios/Vyncint Smith will try to take up the slack.
Sam Ficken, K, NYJ: Groin -- Doubtful
Impact: Sergio Castillo is active, so Ficken likely sits.
Defense
Jerry Hughes, DE, BUF: Foot -- Questionable
Matt Milano, LB, BUF: Pectoral -- Questionable
Josh Norman, C, BUF: Hamstring -- OUT
Micah Hyde, S, BUF: Concussion -- Questionable
Darius Phillips, C, CIN: Knee -- Questionable
Kevin King, CC, GB: Quad -- OUT
Darnell Savage, S, GB: Quad -- Questionable
Holton Hill, CB, MIN: Foot -- OUT
Lawrence Guy, DT, NE: Ankle -- Questionable
John Simon, DE, NE: Shoulder -- Questionable
Stephon Gilmore, C, NE: Knee -- OUT
Jordan Jenkins, LB, NYJ: Ribs -- Questionable
Bradley McDougald, S, NYJ: Shoulder -- OUT/IR
Mike Hilton, CB, PIT: Shoulder -- Questionable
4 p.m. ET games
Offense
Cordarrelle Patterson, WR, CHI: Quad -- Questionable
Impact: Should play in an RB capacity, as WR Allen Robinson II was cleared from the league's concussion protocol.
Phillip Lindsay, RB, DEN: Concussion -- Questionable
Impact: May be a game-time call. Melvin Gordon III will split work with him if he can play.
Diontae Spencer, WR, DEN: Shoulder -- OUT
Impact: Jerry Jeudy and KJ Hamler are the safest options here ...
Tim Patrick, WR, DEN: Hamstring -- Questionable
Impact: ... with Tyrie Cleveland and DaeSean Hamilton also in the conversation.
Jake Butt, TE, DEN: Hamstring -- Questionable
Impact: Albert Okwuegbunam may be a sleeper play at the position.
Tyrod Taylor, QB, LAC: Chest -- Questionable
Impact: Just your weekly reminder that Justin Herbert is the starter for the Chargers.
Michael Thomas, WR, NO: Hamstring -- OUT
Impact: Tre'Quan Smith and Deonte Harris will start for the Saints at WR...
Marquez Callaway, WR, NO: Ankle -- OUT
Impact: ... with Emmanuel Sanders still on the reserve/COVID-19 list.
Carlos Hyde, RB, SEA: Hamstring -- Doubtful
Impact: It's a game-time call for a trio of Seattle backs ...
Chris Carson, RB, SEA: Foot -- Questionable
Impact: ... which means fantasy managers had better have alternatives.
Travis Homer, RB, SEA: Knee -- Questionable
Impact: DeeJay Dallas could well back his way into a start if all three can't go.
Jeff Wilson Jr., RB, SF: Ankle -- OUT/IR
Impact: Tevin Coleman was activated from the IR and will split time with Jerick McKinnon and JaMycal Hasty.
Deebo Samuel, WR, SF: Hamstring -- OUT
Impact: Kendrick Bourne could potentially get a bump in value.
Defense
Khalil Mack, LB, CHI: Ankle -- Questionable
Eddie Jackson, S, CHI: Knee -- Questionable
Jeremiah Attaochu, DE, DEN: Quad -- Questionable
Benson Mayowa, DE, SEA: Ankle -- Questionable
Shaquill Griffin, CB, SEA: Concussion -- OUT
Jamal Adams, S, SEA: Groin -- Questionable
Kwon Alexander, LB, SF: Ankle -- Doubtful
Jaquiski Tartt, S, SF: Groin -- OUT
Jimmie Ward, S, SF: Quad -- Questionable
Sunday night game
Dallas Cowboys
Andy Dalton, QB, DAL: Concussion -- OUT
Impact: Ben DiNucci will start, with Garrett Gilbert as backup. Downgrade all Cowboys.
Philadelphia Eagles
Miles Sanders, RB, PHI: Knee -- OUT
Impact: Boston Scott gets another start. Also, TE Dallas Goedert comes off the IR.
Alshon Jeffery, WR, PHI: Calf -- OUT
Impact: Travis Fulgham and Jalen Reagor will be handling things in Philadelphia.
Cre'Von LeBlanc, CB, PHI: Quad -- OUT
Impact:
Official Sunday inactives should begin coming in at approximately 11:30 a.m. ET for the early games and 2:30 p.m. ET for the late games.