With the Arizona Cardinals trailing the Buffalo Bills by four on Sunday and time for one or two more plays, Cardinals quarterback Kyler Murray scrambled to buy time near midfield. Then he launched a pass in the direction of receiver DeAndre Hopkins.

With three Bills defenders shadowing him, Hopkins disappeared into a pile of bodies and somehow emerged with the ball and a 32-30 Arizona victory.

It's the catch of the year and the play of the season, and it shook up the standings in two divisions.

The sports world was mesmerized. Here's a sample of the reactions:

Don't ever say it's impossible... pic.twitter.com/lqe2UkxsCT

— Deandre Hopkins (@DeAndreHopkins) November 16, 2020

I DONT NEED ANY NOMINEES FOR THIS WEEK!!!Did yaw see @DeAndreHopkins??WOW

— Randy Moss (@RandyMoss) November 16, 2020

WOW WOW WOW!! HOP HOP HOP! @DeAndreHopkins My bro different!!

— LeBron James (@KingJames) November 16, 2020

@DeAndreHopkins is a monster man!!!

— Patrick Mahomes II (@PatrickMahomes) November 16, 2020

ARE....YOU....NOT.....ENTERTAINED! ? @DeAndreHopkins ? ?? pic.twitter.com/kvg7AF3ux9

— Patrick Peterson /P2 (@P2) November 16, 2020

GLOBAL HOPKINS

— Tyrann Mathieu (@Mathieu_Era) November 16, 2020

There are only a select few of us that can make a play like this! Ha https://t.co/7mYbWMOKpF

— Eli Manning (@EliManning) November 16, 2020

DeAndre Hopkins with ONE of the best leaps in Masters Sunday history ... #BUFvsAZ pic.twitter.com/hMa8NK5Dd6

— PGA TOUR (@PGATOUR) November 16, 2020

DEANDRE HOPKINS IS DIFFERENT

— Christian Kirk (@ckirk) November 16, 2020

Never say never, I guess. Wow.

⁦@DeAndreHopkins⁩ ⁦@K1⁩ ⁦@AZCardinals⁩ pic.twitter.com/SOmDO4un30

— Rich Eisen (@richeisen) November 16, 2020

Shiiiiiiiiiiiiid..... Hop down there somewhere! ??‍♂️ @DeAndreHopkins

— Kyler Murray (@K1) November 16, 2020

Deandre Hopkins Moss'd the entire Bills' secondary

pic.twitter.com/PEMvEVXejW

— PFF (@PFF) November 16, 2020