BYU will replace Liberty as Coastal Carolina's opponent on Saturday after COVID-19 issues prevented the Flames from playing in the game.
The game will kickoff at 5:30 p.m. ET and air on ESPNU.
Several Liberty players and staff members, including star quarterback Malik Willis, tested positive or were quarantined this week because of COVID-19. The Flames (9-1) had still hoped to play in the game, but school medical officials would not allow it and paused all team-related activities after Wednesday's test results were returned Thursday morning.
BYU (9-0) and Coastal Carolina (9-0) are both ranked this week in the College Football Playoff rankings. The Cougars are No. 13 and the Chanticleers No. 18.
BYU, which last played Nov. 21, had been looking for another opponent. The Cougars weren't scheduled to play again until Dec. 12 against San Diego State.
"We're grateful that this game between our two teams could be put together in such a timely fashion." BYU athletic director Tom Holmoe said in a statement. "It's good to have a partner like ESPN that can help put together such a meaningful game at this point of the season."
ESPN's College GameDay is set to broadcast Saturday from the Coastal Carolina campus.