SOUTH BEND, Ind. -- Ian Book threw three touchdown passes and ran for two scores in his final home game at Notre Dame, leading the second-ranked Fighting Irish to a 45-21 victory against Syracuse on Saturday.

The fifth-year senior led the Irish to a victory as a starter for the 30th time, the most ever for a Notre Dame quarterback. The Irish (10-0, 9-0 ACC, CFP No. 2) ran their winning streak to 16 games, best in the country, and their home winning streak to 24.

Next up for the Irish, who are playing this season in a pandemic as a member of the Atlantic Coast Conference, is the Dec. 19 league championship game in Charlotte, North Carolina. It will be a rematch against No. 4 Clemson if the Tigers beat Virginia Tech later Saturday.

Book was 24-for-37 for 285 yards, with touchdown passes of 21, 28 and 26 to Javon McKinley, who had seven receptions for 111 yards.

Book scored on runs of 28 and 17 yards and rushed for 53 yards while improving to 30-3 as a starter and passing Notre Dame greats Tom Clements, Ron Powlus and Brady Quinn for most victories as a starting quarterback.

Kyren Williams had 110 yards in 20 carries, giving him 1,011 for the season, and freshman Chris Tyree had a 94-yard TD run for Notre Dame's final touchdown.

The Orange (1-10, 1-9) managed 414 yards on the Irish defense, ranked No. 10 nationally coming into the game, and took a 7-3 lead in the second quarter.

Notre Dame started its scoring run thanks in part to a roughing the passer penalty by Syracuse that Book later turned into a 28-yard TD run. Linebacker Marist Liufau's fumble recovery and return to the Syracuse 21 was followed by Book's first TD pass to McKinley.

Then Book engineered a six-play, 68-yard scoring drive that took only 32 seconds, finishing it with a 28-yard TD pass to McKinley and the Irish were up 24-7 at half.