Ospreys and Connacht are bringing forward their rearranged Pro14 match in Galway to Sunday 24 January, kick-off 15:00 BST.
The original match in late November was postponed after a Welsh regional player returned a positive Covid-19 test.
The game was initially rescheduled for 13 February but has been changed for a second time.
Welsh regions were facing two weeks off after the European Champions Cup and Challenge Cup were suspended.
Ospreys have won five out of the past six games and head coach Toby Booth is keen to avoid a long break.
"We want to keep playing. There's a lot of positivity around the place," he said.
"Winning does that, the culture you have does that, consistency does that. We want to maintain the vibe that you've created within the camp."
Scarlets and Cardiff Blues will meet on 22 January while Dragons will next host Connacht on 5 February.
European Professional Club Rugby (EPCR) says it had "no choice" but to postpone all matches scheduled for the weekends of 16 and 23 January.
It comes after the French government decreed its clubs should not play in the competitions this month.
The Irish inter-provincial derby between Munster and Leinster at Thomond Park has been rescheduled for Saturday 23 January, while Glasgow and Edinburgh will face each other seven days earlier in Scotland.
The final five rounds of league fixtures, which have yet to be released, are due to start on the weekend of 20-21 February and finish in late March.
This season's Pro14 competition has been shortened to 16 rounds to accommodate the new Rainbow Cup from April onwards.
There will be no semi-finals with the two conference winners meeting in the final on 27 March.