Flanker Jamie Ritchie is one of four changes to the Scotland team that hosts Ireland in the Six Nations on Sunday.
Back row Ritchie, who sat out the defeat by Wales through injury, is joined in the XV by wing Sean Maitland, centre Sam Johnson, and prop WP Nel.
It will be Nel's first Test start since the 2019 World Cup.
Blade Thomson, Darcy Graham, James Lang, and the suspended Zander Fagerson drop out of the side that lost 25-24 at Murrayfield a month ago.
Gregor Townsend's men opened with a win in England before losing to Wales.
However, they have not played since after their meeting with France in Paris was called off because of a Covid outbreak in the French camp.
That has yet to be rearranged, but 26 March has been widely mooted as a potential date - just six days after Scotland host Italy.
After losing their opening two games to Wales and France, Ireland go into their fourth match of the campaign on the back of a 48-10 win over Italy in Rome.
Scotland: Hogg (capt); Maitland, Harris, Johnson, Van der Merwe; Russell, Price; Sutherland, Turner, Nel; Cummings, J Gray; Ritchie, Watson, M Fagerson.
Replacements: Cherry, Bhatti, Berghan, Gilchrist, Haining, Steele, H Jones, Graham.
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