Wales wing and centre George North has been ruled out of the British and Irish Lions tour of South Africa after rupturing the anterior cruciate ligament in his right knee.
The 29-year-old suffered the injury on Saturday, playing for Ospreys against Cardiff Blues in the Pro14 Rainbow Cup.
Lions coach Warren Gatland will name his 36-man squad on 6 May.
North tweeted: "Sport can be cruel. I will need surgery next week. Heartbroken is an understatement."
North suffered the problem early in the second half of the 36-14 victory.
He appeared to get his leg stuck in the Liberty Stadium turf and was in notable pain before being helped off the field.
He was featuring on the wing for his region after being used as a centre by Wales coach Wayne Pivac this season.
North played an important role in Wales' 2021 Six Nations title success, impressing at outside centre.
His versatility and experience of playing on previous Lions tours made him a prime candidate to be named in Gatland's squad to tour South Africa in July and August.
It would have been a third Lions tour for North after he was part of the squad in Australia in 2013 and New Zealand four years later.