Exeter's Sam Simmonds is included ahead of fellow England number eight Billy Vunipola in a 37-man British and Irish Lions squad, with two-time tourist Johnny Sexton also left out.
Wales great Alun Wyn Jones is confirmed as captain for what will be his fourth Lions tour.
England forward Courtney Lawes - out injured since February - and lock Jonny Hill are also in the team.
In the centres, Scotland's Chris Harris and Ireland's Bundee Aki are named.
England's Henry Slade is left out as is 2013 tourist Manu Tuilagi, who last played in September because of an Achilles injury.
More to follow.
British and Irish Lions 2021 squad
Captain: Alun Wyn Jones (Wal)
Forwards: Tadhg Beirne (Ire), Jack Conan (Ire), Luke Cowan-Dickie (Eng), Tom Curry (Eng), Zander Fagerson (Sco), Taulupe Faletau (Wal), Tadhg Furlong (Ire), Jamie George (Eng), Iain Henderson (Ire), Jonny Hill (Eng), Maro Itoje (Eng), Wyn Jones (Wal), Courtney Lawes (Eng), Ken Owens (Wal), Andrew Porter (Ire), Sam Simmonds (Eng), Rory Sutherland (Sco), Justin Tipuric (Wal), Mako Vunipola (Eng), Hamish Watson (Sco).
Backs: Josh Adams (Wal), Bundee Aki (Ire), Dan Biggar (Wal), Elliot Daly (Eng), Gareth Davies (Wal), Owen Farrell (Eng), Chris Harris (Sco), Robbie Henshaw (Ire), Stuart Hogg (Sco), Conor Murray (Ire), Ali Price (Sco), Lewis Rees-Zammit (Wal), Finn Russell (Sco), Duhan van der Merwe (Sco), Anthony Watson (Eng), Liam Williams (Wal).
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