Los Angeles Angels star outfielder Mike Trout is expected to miss six to eight weeks with a right calf strain, the team announced.
He was placed on the 10-day injured list Tuesday after exiting Monday night's game against Cleveland after the first inning.
The outfielder was limping after running to third on an inning-ending popup. Los Angeles manager Joe Maddon said after his team's 7-4 victory that Trout was undergoing further evaluation, including an MRI.
"I saw nothing. I looked up and he was limping to the third base bag,'' Maddon said. "It was kind of innocuous, and I had no idea why. It was hurting him pretty good.''
The three-time MVP entered Monday sixth in the American League with a .333 batting average but was 1-for-17 in his past six games. He snapped a five-game hitless streak Sunday at Boston, which was one game shy of the longest of his career.
Trout has missed at least 22 games in each of the past three 162-game seasons. He missed no more than five in each of his first four full seasons in the majors.
The Associated Press contributed to this report.