BALTIMORE -- Orioles starting pitcher John Means left Saturday's game against the Cleveland Indians with two outs in the first inning because of what the team said was left shoulder fatigue.

The left-hander allowed solo home runs to Cesar Hernandez and Harold Ramirez, then left after Eddie Rosario's two-out single. Manager Brandon Hyde then came to the mound along with head athletic trainer Brian Ebel, and Means exited the game.

Adam Plutko replaced Means, who threw a no-hitter at Seattle on May 5.

Means (4-1) had gone at least five innings in all but one of his 11 starts this season. His 2.05 ERA ranks second in the American League, while his .173 opponents' batting average is third in the league.