Alize Cornet upset Bianca Andreescu for the second time in two weeks by beating the fifth-seeded Canadian 6-2, 6-1 in the first round at Wimbledon on Wednesday.

Cornet, who also beat Andreescu in Berlin two weeks ago, broke the former US Open champion five times and sealed the victory by chasing down a shot and hitting a lob that landed just inside the baseline on match point.

With Andreescu's loss, No. 6 Serena Williams being forced to withdraw midmatch Tuesday with a leg injury and No. 10 Petra Kvitova falling to Sloane Stephens on Monday, this marks the second time ever at Wimbledon that three top-10 women's seeds have lost in the first round, along with 2018, when four went out in their opening matches.

French Open runner-up Anastasia Pavlyuchenkova cruised into the second round with a 6-2, 6-2 win over Ana Bogdan.

The 16th-seeded Pavlyuchenkova took advantage of 16 unforced errors from Bogdan to win in under an hour. She reached her first Grand Slam final at Roland Garros before losing in three sets to Barbora Krejcikova.

Camila Giorgi and 19th-seeded Karolina Muchova also advanced to the second round. They were among 27 first-round matches that had not been started or completed during the first two days because of rain delays.

The Associated Press contributed to this report.