Champions Harlequins inflicted a first home defeat in over three years on Saracens with a 36-17 bonus-point win in the Premier 15s.
Saracens took the lead through hooker May Campbell with a line-out move off the training field, but Quins bounced back after Jade Konkel powered over.
Fiona Fletcher crossed for the visitors before Emily Scott burst through.
Sarah Beckett added a fourth before Konkel scored the fifth late on, while Hannah Botterman scored a consolation.
Defeat for Saracens means they remain second in the table, while third-placed Quins sit four points behind.
Bristol Bears lead the way after returning to winning ways with a narrow victory at Worcester Warriors on Saturday.
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