Ross Moriarty will make his first appearance in three months when he captains Dragons against Benetton in the United Rugby Championship.
The British and Irish Lions back row has been released from the Wales squad to prove his fitness ahead of the Six Nations.
Sam Davies plays his 150th league game as he makes a 50th Dragons appearance.
Wales internationals Elliot Dee and Rhodri Williams are named on the bench having returned from injury.
The sides meet for a second time this month after Dragons were beaten 23-9 in Benetton in the European Challenge Cup.
Flanker Ollie Griffiths is also back in the Dragons side as director of rugby Dean Ryan makes nine starting changes.
Aki Seiuli comes into the front row, Adam Warren is at centre, while there will be a new look back three of Jonah Holmes, Jordan Olowofela and Josh Lewis.
Dragons are in desperate need of a win having lost nine of their last 10 competitive matches this season.
They are currently 14th in the table, while Benetton are seventh having played one game more.
Benetton are also all change with Tommaso Benvenuti and Lorenzo Cannone the only survivors from the side defeated by Lyon last weekend, although both make positional switches.
Dragons: Lewis; Holmes, Warren, Owen, Olowofela; S Davies, Bertranou; Seiuli, T Davies, Coleman, J Davies, Maksymiw, Keddie, Griffiths, Moriarty (capt)
Replacements: Dee, Reynolds, Doge, Taylor, Baker, Williams, Rosser, I Davies.
Benetton: Da Re; Pani, Drago, Riera, Benvenuti; Albornoz, Duvenage (capt); Gallo, Els, Tetaz, Herbst, Wegner, Meggiato, Lazzaroni, Cannone.
Replacements: Faiva, Traore, Alongi, Piantella, Steyn, Garbisi, Zanon, Bell.
Dragons director of rugby Dean Ryan: "We recognise all Italian sides are big up front.
"I thought they strangled us a little bit in terms of high ball and contest on the ground.
"For us to try and get away from that we need to be better in those areas because we couldn't get into the game that we wanted to play.
"We've got to increase the pace of the game and to do that we've got to control the breakdown and if we can do that hopefully we can get a little bit more movement."
Match officials
Referee: Andrew Brace (IRFU)
Assistant referees: Jason Bessant (WRU) John Darcy (WRU)
TMO: Jon Mason (WRU)
Phone: (800) 737. 6040
Fax: (800) 825 5558
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