Wing Henry Arundell will make his first England start while Owen Farrell returns at fly-half for their final Six Nations game against Ireland.
Farrell comes back in as captain at 10 after being dropped for Marcus Smith in the record home defeat by France.
Manu Tuilagi is named at inside centre for the injured Ollie Lawrence for his first England appearance under England head coach Steve Borthwick.
David Ribbans replaces the injured Ollie Chessum in the second row.
England will be hoping to bounce back from their humiliating defeat by France last weekend and prevent Ireland from winning the Grand Slam in Dublin.
Smith drops to the bench after being promoted to the starting line-up in an attempt to inspire the attack against France.
Lewis Ludlam is rewarded for his form with a vice-captain's role, alongside prop Ellis Genge.
Dan Cole will win his 100th Test cap if he is brought on as a replacement at the Aviva Stadium.
"We know that after the bitter disappointment of the display against an exceptional France team last week, we will have to be much improved to meet the challenge of playing the side presently ranked number one in the world," said Borthwick.
"However, I have witnessed an England squad determined to make amends for the defeat at Twickenham, and I am confident that the team announced today will once again want to show the sort of resilience and attitude that brought us victory in Wales."
England: Steward; Watson, Slade, Tuilagi, Arundell; Farrell (c), Van Poortvliet; Genge, George, Sinckler, Itoje, Ribbans, Ludlam, Willis, Dombrandt
Replacements: Walker, M Vunipola, Cole, Isiekwe, B Curry, Mitchell, Smith, Marchant
Ireland: Keenan; Hansen, Henshaw, Aki, Lowe; Sexton (c), Gibson-Park; Porter, Sheehan, Furlong; Baird, Ryan; O'Mahony, van der Flier, Doris.
Replacements: Herring, Healy, O'Toole, Treadwell, Conan, Murray, R Byrne, O'Brien.