NEW YORK -- Daniil Medvedev ended Carlos Alcaraz's reign as the US Open champion by eliminating him in the semifinals 7-6 (3), 6-1, 3-6, 6-3 on Friday night to set up a rematch in the final against Novak Djokovic.

The No. 3-seeded Medvedev won his lone major title at Flushing Meadows in 2021 by defeating 23-time Slam winner Djokovic in that year's final.

That prevented Djokovic from completing what would have been the first calendar-year Grand Slam in men's tennis since 1969.

The top-seeded Alcaraz -- a 20-year-old from Spain who will relinquish the No. 1 ranking to Djokovic no matter what happens on Sunday -- had been trying to become the first man to claim consecutive championships in New York since Roger Federer won five in a row from 2004-08.

Ever since before the start of these two weeks, folks had been anticipating a Djokovic vs. Alcaraz final. That would have been a rematch of the trophy-determining match at Wimbledon in July, when Alcaraz edged Djokovic in five sets.

Instead, it will be Medvedev, a 27-year-old from Russia, who will be appearing in his third US Open final in five years and his fifth major title match in all.

He lost to Rafael Nadal in New York in 2019, and to Djokovic at the Australian Open in 2021 and 2022.

"The challenge is that you play a guy that won 23 Grand Slams, and I have only one," Medvedev said, looking ahead to taking on Djokovic. "When I beat him here, I managed to play better than myself, so I need to do it again. There is no other way."

Medvedev had lost to Alcaraz twice this season, including in the Wimbledon semifinals. Those head-to-head results left Medevev concerned.

"Before the match, for sure, a lot of doubts," he said.

But Medvedev, in his words, played at a "12 out of 10" to defeat a world No. 1 for the sixth time -- the only active players with more wins over ATP No. 1s are Nadal (23), Djokovic (16) and Andy Murray (12) -- and continue his unparalleled success on hardcourt. Since the start of 2018, nobody has recorded more match wins (235), final appearances (28) and titles (18) on hardcourts than Medvedev.

ESPN Stats & Information and The Associated Press contributed to this report.