Ireland head coach Andy Farrell says the decision to leave experienced trio Johnny Sexton, Keith Earls and Cian Healy out of his summer Test squad was made to ensure the players could have a full and uninterrupted pre-season.
Farrell named 11 uncapped players in his 37-man squad for July's fixtures against Japan and the USA.
Leinster lock James Ryan will captain the side, with John Cooney, Eric O'Sullivan, Gavin Thornbury and James Lowe among those unavailable through injury.
Regular captain Sexton, 35, has been given the summer off along with experienced campaigners Healy and Earls, allowing them to participate in a full pre-season with their provinces.
"For Johnny, Cian and Keith they'll probably get eight or nine weeks of a pre-season, other lads will probably get four or five," Farrell explained.
"These lads understand that, their competitive nature won't totally agree with that but at the same time for them to have proper rest that they need, and on top of that come back and have a proper season where they can make gains and come back into the start of the new season with a fire burning rapidly is going to benefit us all in the long run."
Ulster trio Robert Baloucoune, Tom O'Toole and Nick Timoney are among the uncapped players to have been called up.
Munster back rows Fineen Wycherley and Gavin Coombes are included following their impressive club form, with Connacht's Caolin Blade, Tom Daly and Paul Boyle also named.
Fly-half Harry Byrne is hoping to make his first appearance as are his Leinster team-mates Peter Dooley and Ross Molony.
There are recalls for Munster fly-half Joey Carbery and Ulster back Will Addison, neither of whom have played for Ireland since 2019 having suffered lengthy injuries.
Hooker Ronan Kelleher is included in the squad, having been called-up to train with the British and Irish Lions squad this week, but not formally added to the touring party.
Sexton to wait for 100th cap
Sexton, who missed out on a place in Warren Gatland's Lions squad, will now have a rare summer off meaning he will not win his 100th Ireland cap until autumn at the earliest.
The Leinster fly-half made his 99th international appearance in March's Six Nations win over England.
There is no place in the squad for Jack Carty or Sexton's provincial understudy Ross Byrne, with his younger brother Harry one of three fly-halves selected.
Ulster's Billy Burns is included, as Carbery's return provides a welcome sight for Ireland fans, many of whom viewed him as the likeliest candidate to challenge Sexton for the starting number 10 jersey prior to his ankle injury.
There is also excitement to see Munster's young back rows Wycherley and Coombes on the international stage, with the latter capping a fine season with four tries against Zebre on Friday.
Ryan, who has captained the side previously in Sexton's absence, will hope to shake off the disappointment of missing out on a Lions tour, as will centre Garry Ringrose.
Ireland will meet the Japan on 3 July at the Aviva Stadium before hosting the USA at the same venue a week later.
Lions door remains open to Farrell
There is still a possibility that Farrell may link up with the Lions after Ireland's two matches.
He formed part of the coaching staff on the last two tours and was made available to the Lions, who will make a decision on the need to bring him on board once the tour is underway.
"I've spoken to Warren a couple of times, I'm more than happy to help out because it's an unbelievable honour to be asked or involved," said Farrell.
"Warren has left a spot open there and he wants to see how the workload goes in the first week or so of the camp. If he needs help in and around all that I'm happy to help."
Ireland squad for July Tests
Backs: Will Addison, Robert Baloucoune*, Caolin Blade*, Billy Burns, Harry Byrne*, Joey Carbery, Craig Casey, Andrew Conway, Shane Daly, Tom Daly*, Chris Farrell, Jamison Gibson-Park, Hugo Keenan, Jordan Larmour, Stuart McCloskey, Garry Ringrose, Jacob Stockdale.
Forwards: Ryan Baird, Finlay Bealham, Paul Boyle*, Ed Byrne, Gavin Coombes*, Ultan Dillane, Peter Dooley*, Caelan Doris, Dave Heffernan, Rob Herring, Ronan Kelleher, Dave Kilcoyne, Ross Molony*, Peter O'Mahony, Tom O'Toole*, James Ryan (capt), John Ryan, Nick Timoney*, Josh van der Flier, Fineen Wycherley*.
* denotes an uncapped player.